|4,5,6,7-四溴-1H-苯并三唑|CsnPharm

CAS No.: 17374-26-4

4,5,6,7-Tetrabromo-1H-benzo[d][1,2,3]triazole Catalog No. CSN19438

Synonyms: NSC 231634;Casein Kinase II Inhibitor I;2-乙基己基-四溴苯甲酸

TBB is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2)with IC50s of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively).

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靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 Casein Kinase 2 (rat liver)

IC50:0.9μM Casein Kinase 2

IC50:1.6μM
描述The inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) is a selective inhibitor for the protein kinase CK2 (IC50 1.6 micro m)^[3]. TBB also inhibits three other kinases with less potency: CDK2 (IC50=15.6 μM), phosphorylase kinase (IC50=8.7 μM) and glycogen synthase kinase 3β (GSK3β) (IC50=11.2 μM). All other kinases tested have IC50 values 50-fold greater than that for CK2^[4]. The viability of the androgen insensitive PC-3 cells may be diminished by TBB (60 μM TBB) acting either alone or combined with anticancer agents CPT or TRAIL when a proper time schedule of the administration is applied. The time schedule-dependent activity of TBB does not come from its effect on apoptosis in PC-3 cells^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02235779	Interstitial Lung Disease	Not Applicable	Unknown	December 2016	Canada, Quebec ... more >> Institut universitaire de cardiologie et de pneumologie de Québec Recruiting Québec, Quebec, Canada, G1V 4G5 Contact: Antoine Delage, MDCM 418-656-4747 antoine.delage@criucpq.ulaval.ca Principal Investigator: Antoine Delage, MDCM Sub-Investigator: Simon Martel, MD Sub-Investigator: Steeve Provencher, MD Sub-Investigator: Genevieve Dion, MD Sub-Investigator: Philippe Joubert, MD Sub-Investigator: Massimo Conti, MD Sub-Investigator: Paula Ugalde, MD Collapse <<
NCT03355586	-	-	Recruiting	February 1, 2019	Netherlands ... more >> Radboudumc Recruiting Nijmegen, Gelderland, Netherlands, 6525GA Contact: Erik van der Heijden, MD 00312410325 Erik.vanderheijden@radboudumc.nl Principal Investigator: Erik van der Heijden, MD Collapse <<
NCT01011543	Pulmonary Tuberculosis	Not Applicable	Completed	-	Belgium ... more >> CHU St Pierre; pulmonology department Brussels, Belgium, 1000 Collapse <<

更多
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3004 mL
- 11.5020 mL
- 23.0039 mL
- 5 mM
- 0.4601 mL
- 2.3004 mL
- 4.6008 mL
- 10 mM
- 0.2300 mL
- 1.1502 mL
- 2.3004 mL

技术信息

CAS号

17374-26-4

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C6HBr4N3

运输

蓝冰

分子量

434.71

别名

NSC 231634;Casein Kinase II Inhibitor I;2-乙基己基-四溴苯甲酸

溶解度

DMSO	86.0 mg/mL (197.8 mM)

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02235779	Interstitial Lung Disease	Not Applicable	Unknown	December 2016	Canada, Quebec ... more >> Institut universitaire de cardiologie et de pneumologie de Québec Recruiting Québec, Quebec, Canada, G1V 4G5 Contact: Antoine Delage, MDCM 418-656-4747 antoine.delage@criucpq.ulaval.ca Principal Investigator: Antoine Delage, MDCM Sub-Investigator: Simon Martel, MD Sub-Investigator: Steeve Provencher, MD Sub-Investigator: Genevieve Dion, MD Sub-Investigator: Philippe Joubert, MD Sub-Investigator: Massimo Conti, MD Sub-Investigator: Paula Ugalde, MD Collapse <<
NCT03355586	-	-	Recruiting	February 1, 2019	Netherlands ... more >> Radboudumc Recruiting Nijmegen, Gelderland, Netherlands, 6525GA Contact: Erik van der Heijden, MD 00312410325 Erik.vanderheijden@radboudumc.nl Principal Investigator: Erik van der Heijden, MD Collapse <<
NCT01011543	Pulmonary Tuberculosis	Not Applicable	Completed	-	Belgium ... more >> CHU St Pierre; pulmonology department Brussels, Belgium, 1000 Collapse <<
NCT01785433	COPD	Phase 1 Phase 2	Completed	-	Germany ... more >> Teva Investigational Site 32170 Berlin, Germany Teva Investigational Site 32169 Gauting, Germany Teva Investigational Site 32171 Grosshansdorf, Germany Teva Investigational Site 32167 Mannheim, Germany Teva Investigational Site 32168 Wiesbaden, Germany Collapse <<
NCT02203474	Chronic Obstructive Pulmonary ... more >>Disease COPD Collapse <<	Phase 2	Withdrawn	-	-
NCT00888212	Sarcoidosis	Not Applicable	Completed	-	Belgium ... more >> OLV Ziekenhuis Aalst Aalst, Belgium Universitair Ziekenhuis Antwerpen Antwerp, Belgium ZNA Antwerpen Antwerp, Belgium AZ St. Jan Hospitaal Brugge Brugge, Belgium Cliniques Universitaires St. Luc Brussels, Belgium University Hospital Brussels Brussels, Belgium Höpital Erasme Brussel Brussel, Belgium CHU Charleroi Charleroi, Belgium University Hospital Ghent Ghent, Belgium, 9000 Virga Jesse Hospitaal Hasselt, Belgium UZ Gasthuisberg Leuven Leuven, Belgium Heilig Hartziekenhuis Menen Menen, Belgium Hôpital Saint Elisabeth Namur Namur, Belgium AZ Oudenaarde Oudenaarde, Belgium Netherlands Ampha Ziekenhuis Breda Breda, Netherlands Collapse <<
NCT03329807	Stroke	Not Applicable	Recruiting	August 30, 2019	Brazil ... more >> Federal University of Pernambucano Recruiting Recife, Pernambuco, Brazil, 50740-560 Contact: Katia Monte-Silva, phd +55(81)21267579 monte.silvakk@gmail.com Aristela de Freitas Zanona Recruiting Recife, Brazil Contact: ARISTELA ZANONA +5579991215051 arisz_to@yahoo.com.br Collapse <<
NCT01894113	Interstitial Lung Disease	Not Applicable	Completed	-	Germany ... more >> University Hospital Tuebingen Tuebingen, Germany Collapse <<
NCT01704547	-	-	Completed	-	United States, Maryland ... more >> Ummc Msgcc Baltimore, Maryland, United States, 21201 Collapse <<
NCT01748279	COPD	Phase 4	Completed	-	Poland ... more >> Department of Lung Diseases and Tuberculosis, Medical University of Bialystok Bialystok, Poland, 15-540 Collapse <<
NCT00626587	Peripheral Pulmonary Lesions	Not Applicable	Completed	-	Taiwan ... more >> Chang Gung Memorial Hospital-Kaohsiung Medical Center Niaosung Shiang, Kaohsiung, Taiwan, 833 Collapse <<
NCT03573362	Sarcoidosis L... more >>ymphoma Adenopathy Hilar Collapse <<	Not Applicable	Not yet recruiting	December 2020	-
NCT03274609	-	-	Recruiting	February 1, 2019	Netherlands ... more >> Radboudumc Recruiting Nijmegen, Gelderland, Netherlands, 6525GA Contact: Erik van der Heijden, MD 0031243610325 Erik.vanderheijden@radboudumc.nl Principal Investigator: Erik van der Heijden, MD Collapse <<

靶点	Description	IC50
Casein Kinase 2 (rat liver)		IC50:0.9μM
Casein Kinase 2		IC50:1.6μM

4,5,6,7-Tetrabromo-1H-benzo[d][1,2,3]triazole Catalog No. CSN19438

靶点选择性

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